Roxas is a character from a populair video game series called kingdom hearts.
The base of this meme is a cutscene where roxas enters a room, and gets a flashback. But in the meme this is changed to a random thing such as a annoying vid.

The original video that is launched by draik88 on august 27th, 2006:

and this is a popular remake:launched by garra1300 on February 9th, 2007