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My Last Brain Cell

Updated Jan 29, 2025 at 07:57PM EST by LiterallyAustin.

Added Dec 13, 2017 at 01:05PM EST by Matt.

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About

My Last Brain Cell is a series of image macros that personify an overworked, threatened or exhausted brain cell for humorous effect.

Origin

The earliest known usage of a personified brain cell was featured on an episode of Family Guy, entitled "Wasted Talent," which first aired on July 25th, 2000.[2] In the episode, the main character, Peter, drinks so much alcohol that when the show shows the inside his brain, where one lonely brain cell remains. In a reference to The Twilight Zone episode “Time Enough at Last,” the brain cell decided to spend its time reading, only to break its glasses (shown below).


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The earliest known example of someone personifying their brain cell in an image macro was posted by Twitter [1] user @Heart_break_kxd on May 25th, 2016. That day, they posted a still from the Family Guy episode with the caption "Me tonight: Drunk My last brain cell tonight: Where tf everybody at?" (shown below).



Spread

On October 3rd, 2016, Twitter[3] user @fatbully14 tweeted a screenshot from SpongeBob SquarePants. It features a group of angry fish ganging up on a smiling elderly fish with the caption "weed vs my last brain cell." The post (shown below, left) would be the first in a series of "brain cell" memes to feature the image (examples below, center and right)



On December 9th, 2017, the Twitter[4] account @GirlPosts captioned a screenshot from the reality series Flavor of Love[5] "me to my last brain cell for re-learning everything this semester for the comprehensive finals." The picture features to contestants hugging and the subtitle "You're the only bitch in the house that I ever respected." The post (shown below) received more than 1,400 retweets and 6,200 likes in less than one week.



Several days later, on December 12th, Redditor guessingguy [6] posted in the /r/memeeconomy subreddit, "Brain cell memes are rising in popularity, but are susceptible to normifying. Invest with caution." The post (shown below) featured a screenshot from BuzzFeed Unsolved of a man with a face mask saying "Who's a milky piggy? Me, me, me." The post was captioned "Me: ok just one more essay before finals, we can do it / My last brain cell:" Guessingguy's post received more than 100 points (98% upvoted) in 24 hours.



Various Examples




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