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The Weekly Meme Roundup: Pouch GF, Tylenol Autism Announcement, RaptureTok, All Roads Lead To Rome And More


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Published September 26, 2025

Howdy rapture survivors. Welcome to another edition of the Weekly Meme Roundup, where we take five of the biggest memes of the past week and shove them down your throats like a pregnant woman popping Tylenol.

This week, the most vocal people on social media got into arguments over a woman's so-called pouch, TikTokers learned that all roads lead to Rome, interpreting the saying in perhaps the bleakest way possible, and memes entered an annoying new level of niche over on TikTok.

Here are five of the biggest memes of the past week that you should know about.

Zoe Kalotheos "Pouch GF" Post

A fairly offline woman apparently named Zoe Kalotheos became one of the hottest subjects of discourse this past week after a weight loss image went viral on 4chan.


Kalotheos originally went viral in 2023, when someone on 4chan's /fit/ board posted a photo of her and another woman, circling Kalotheos' abdomen, writing, "My gf has a pouch like pic and it doesn't seem to go away no matter how hard she hits the gym. Is surgery my only hope?"

Whether this was meant to be rage bait or not, it became rage bait after the post was screenshotted and shared around social media this year, inspiring heated arguments wherever it shows up. Mostly, those arguments come from people defending Kalotheos's looks and suggesting she looks great with her so-called "pouch."

However, the most recent discourse about Kalotheos surrounds a new alleged photo of her in a bikini post-pouch. That's right: if this photo is authentic (which is hard to confirm since her Instagram account is private), she seems to have lost weight.

Apparently, that's enough to start a new wave of arguing online, with many now mourning the loss of the pouch and hurling Ozempic accusations at the poor woman. Classic internet acting normal toward women. You've done it again.

Examples


All Roads Lead to Rome

The old saying, "All roads lead to Rome," has made a big comeback on TikTok as a lowkey incel-coded way of basically saying, "All girls are the same."


The saying itself has been prominent as a meme for over a decade. It's derived from French poet Alain de Lille, who, in 1175, said, "A thousand roads lead a man forever towards Rome," referring to the structure of Ancient Rome's roads.

Basically, the saying has come to mean that no matter what method or route you use to achieve a certain goal, you will always end up in the same place.

Throughout the 2010s and 2020s, dozens of memes playing with the phrase have gone viral on sites like Reddit, most of them simply pointing fun at the idea of every single road literally leading to Rome.

Now, TikTokers have taken that saying, combined it with the White Rabbit Pointing at a Clock meme, and intertwined it with screenshots of DMs where women break up with or give men false hopes.

These videos seem to suggest that every relationship leads to heartbreak, making this one of the more depressing but undeniably prevalent memes of the week.

Examples


RaptureTok

The Rapture was supposed to happen on September 23rd, but unless literally everyone was left behind, that doesn't seem to have come true. At least we got some good memes and concerning videos out of it.


A lot of these videos come from the good people over at TikTok, where the term "RaptureTok" was coined to define the community of people hyping up the supposed end of the world.

One of these people was a TikTok mom who goes by Brianna, who posted many videos claiming the rapture was happening. She even claimed that her child started talking Hebrew, leading up to the faulty rapture, which she took as just one more sign that it was going to happen, no matter how many Hebrew-speaking viewers insisted he wasn't speaking their language.

Apparently, a lot of people thought this rapture was going to happen. Someone on X even said that their therapist closed his practice to get ready for the event. Maybe that was for the best.

Now, TikTokers are making parody apology videos, posing as people who promised the rapture only for it to never come. You win this round, atheists.

Examples




NicheTok (Purple Plate, Dudeman, My Mother Ate Fries, Homelander Blow, etc.)

Buckle up, people. Memes are getting even more niche over on TikTok to the point where there's now a term for the phenomenon: "NicheTok."


NicheTok is probably best seen as an offshoot of brainrot. It's all about hyping up the most niche, underground memes possible and ironically bragging about being into them before everyone else, mostly by using the Kirk Franklin Eating An Apple format. The memes advertised in these videos are so niche that most of them don't even exist before the videos promoting them, such as the Purple Plate meme.

So, basically, the meme is about tricking people into believing stupid, niche memes exist or are in any way popular, then hoping that they actually turn into something. I guess we're embracing forced memes now.

In stark contrast to the claims of a meme drought earlier this year, TikTokers are now claiming that we're experiencing a meme rush, and it's very much thanks to meme trends like this.

We're looking at you, Fa Mulan, Totr, Dudeman and the rest. You know who you are.

Examples


Tylenol Autism Announcement

Finally, the world was filled with shock and doubt this week when the President of the U.S. held an autism announcement press conference and claimed that taking Tylenol while pregnant might cause autism in kids.


The claim has been met with a lot of mixed reactions. Many medical professionals are suggesting that there is no proven link between autism and Tylenol, as they have been for years.

Regardless, this is the world we live in now, and at least we could get some fun out of it with a whole wave of memes about the effects of Tylenol and an unintentionally funny Fox News graphic that shows the President and the Secretary of Health's faces next to the boldly colored phrase, "AUTISM ANNOUNCEMENT." The memes write themselves.

The day of the announcement, people began editing the banner to replace the faces next to the text. They also started redefining the meaning of "autism announcement" with jokes about the types of announcements that autistic people might make, using the graphic to add an air of grandeur to said announcements.

Isn't making jokes about this whole mess a better response than chugging Tylenol and ending up in the hospital? We think so.

Examples



We'll be back next Friday with another edition of our Weekly Meme Roundup series, so stay tuned!


Tags: weekly meme roundup, niche memes, nichetok, zoe kalotheos, totr, autism tylenol, rapture, rapture 2025, rapturetok, autism announcement, memes of the week, motw, best memes september 2025, top meme september 2025, tylenol memes,



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