Roguelikes have been a popular genre of video games lately. For some reason, people are into the idea of endless striving and struggling. The Binding of Isaac was an early example from famed indie developer Edmund McMillen where you play as a little boy named Isaac whose only weapons are his tears. The game recently got a massive update that integrates fan content with entirely new mechanics and story elements. It's rekindled some interest in the decade-old game, but it's never fallen out of style, especially in meme culture.
At The Mercy Of Chance
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Luck Of The Draw
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New Items Every Time
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Some Items Can Break The Whole Game
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Combination Makes Synergy
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Don't Underestimate Anything Small
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Have A Little Faith
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Hurt Me Plenty
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Having A Blast
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Submit To The Conflagration
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Don't Rely Too Much On Strength
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Big Things Come In Small Packages
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Play The Smart Way
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Don't Waste Your Best Stuff
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Not The First Incarnation
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New And Improved
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Rewards Are Only For The Faithful
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You Can Always Dig Deeper
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A Bitter Pill To Swallow
(Source: Reddit)